IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic analogue of human IGF-1, modified with an N-terminal 13-amino acid extension and an Arg→Arg substitution at position 3. These modifications reduce IGF binding protein (IGFBP) affinity by more than 1000-fold compared to native IGF-1, dramatically extending its plasma half-life and bioavailability in research models. It binds and activates the IGF-1 receptor (IGF-1R), stimulating downstream PI3K/Akt and MAPK/ERK pathways. For research use only.

What is IGF-1 LR3 used for in research?

IGF-1 LR3 is studied in skeletal muscle hypertrophy models, cell proliferation and differentiation research, metabolic regulation studies, and anabolic signalling pathway research. Its reduced IGFBP binding makes it a preferred research tool for studying isolated IGF-1R activation over extended periods compared to native IGF-1. For research use only.

🇦🇺 Australian-Owned Supplier · Janoshik Verified · Wholesale Pricing

Buy IGF-1 LR3 in Australia

IG10 — 1mg per vial, box of 10 research-grade vials. Long R3 IGF-1 analogue with reduced IGFBP binding — the research-preferred form for studying isolated IGF-1R activation. Extensively studied in muscle hypertrophy, cell proliferation, and metabolic signalling models. See published product reports for batch-specific testing information. For research use only.

View Products and Pricing View Sermorelin

Research Use Only: All products are for qualified laboratory research purposes only — not for human therapeutic use or consumption. Subject to applicable Australian regulatory requirements.

What Is IGF-1 LR3?

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic 83-amino acid analogue of human IGF-1, modified at two positions: an N-terminal 13-amino acid extension and substitution of Glu→Arg at position 3. The critical consequence of these modifications is a greater than 1000-fold reduction in affinity for all six insulin-like growth factor binding proteins (IGFBPs 1-6), which in native IGF-1 account for the majority of plasma binding and limit free IGF-1 concentrations.

By bypassing IGFBP sequestration, IGF-1 LR3 displays a dramatically extended effective half-life in research models, making it the preferred research tool for studying sustained IGF-1 receptor (IGF-1R) activation. Downstream signalling via PI3K/Akt (anabolic/survival) and MAPK/ERK (proliferative) pathways is well-characterised in the preclinical muscle, metabolic, and oncology research literature.

For GH axis upstream research, see Sermorelin or CJC-1295(without DAC)+ Ipamorelin (5/5mg). For research use only.

IGF-1 LR3 Products

Supplied as lyophilised powder in boxes of 10 research-grade vials.

IG10

IGF-1 LR3 1mg

Box of 10 vials · 1mg per vial

$1,188.00 per box

✓ Janoshik COA published on product page
✓ Review batch-specific test results
✓ Free shipping
✓ View available reports on the product pages

View full product page + COA

Frequently Asked Questions

Where can I buy IGF-1 LR3 in Australia? +

Eternal Peptides Wholesale is an Australian-owned, online distributor supplying IGF-1 LR3 for research purposes. IG10 (1mg, box of 10) is $1,188.00. Janoshik-verified with COA on product page. see Shipping Policy for dispatch estimates. For research use only.

Why use IGF-1 LR3 instead of native IGF-1? +

Native IGF-1 is heavily sequestered by IGFBPs in plasma, which limits free IGF-1 and shortens its effective half-life. IGF-1 LR3's >1000-fold reduced IGFBP affinity means it remains bioavailable for IGF-1R activation over much longer timeframes — making it the research-preferred form for studying sustained IGF-1R-mediated signalling. For research use only.

What pathways does IGF-1 LR3 activate in research models? +

IGF-1 LR3 activates the IGF-1 receptor (IGF-1R), stimulating PI3K/Akt/mTOR signalling (protein synthesis, cell survival, anabolic) and MAPK/ERK signalling (cell proliferation, differentiation). These pathways are central to skeletal muscle hypertrophy, metabolic regulation, and cell growth research. For research use only.

How is IGF-1 LR3 quality verified? +

Review the published reports for the selected product and batch. Only the tests and results shown on those reports apply; do not assume additional methods or testing were performed.

How quickly is IG10 dispatched? +

Consult our Shipping Policy for processing and delivery estimates. Dispatch origin can vary, including offshore fulfilment; Australian business ownership does not guarantee domestic stock or customs-free delivery. View available reports on the product pages.